New perspectives in the management of hypertension: role of herbal medicines

To compare the efficacy of coded herbal medicine [Hyprol] and losartan in hypertensive type II diabetic patients. Case control study. This study was carried out at the Out-patient Department of JPMC, Karachi and Herbal Clinics of Karachi from January 2014 to June 2014. This study is a case control prospective study to compare the effects of Losartan with herbal medicine [Hyprol] in type 2 diabetic hypertensive patients. 200 patients were enrolled and divided in two groups [A] [Control group] and [B] [Test group] treated with Losartan and Hyprol respectively. With ARB [Losartan] baseline to final change for SBP as well as DBP was significantly reduced i.e. 22.45% [p<0.001] and 16.84% [p<0.001] respectively and FBS was reduced by 21.85% [p<0.001] while Hyprol shows comparable results i.e. difference in SBP, DBP and FBS was 14% [p<0.001], 15.31% [p<0.001], 34.57% [p<0.001] respectively. ARBs are the first line drug of choice for hypertension since long time. Use of herbal medicine is an alternative mean of therapy to treat these patients and limit its cardiovascular and renal complications

Clinical evaluation of coded herbal medicine [hypoess] and angiotensin receptor blocker [candesartan] in essential hypertensive patients

The basic aim of this research study was to determine the comparative effect of herbal treatment in comparison with standard allopathic medicine in control and treatment of essential hypertensive patients. Prospective and comparative study. This study was carried out in Department of Pharmacology, HCM and D, FH and MS, Hamdard University, Karachi, from January 2014 to July 2014. A total of 200 patients were enrolled in study and were given Hypoess in one hundred patients while remaining one hundred patients received allopathic medicine Candesartan. In test group one hundred patients were treated with herbal drug [Hypoess] and it decreased mean systolic blood pressure of study patients with a decrease of 15.17% whereas, a reduction of 20.56% was found with allopathic medicine Candesartan Cilexetil. Similarly a decrease of 18.07% was found in mean diastolic blood pressure with herbal medicine in test group patients and a decrease of 21.65% was observed in case of allopathic drug in mean diastolic blood pressure of control group patients. The effects of herbal medicine were found statistically significant in controlling blood pressure and it has been found as an alternative option to treat essential hypertensive patients with its cost-effectiveness

Reciprocity of calcium response in doxorubicin treated heart

Doxorubicin is an important anthracycline which has proven anticancer activity. However its clinical use has been limited by its cardiotoxicity. Many studies have been conducted to explore the mechanism of this untoward effect, but have given conflicting data. This study has been conducted to determine the role of calcium in this regard. Langendroff's technique was used. The data obtained from a significant number of rabbits shows that Doxorubicin suppresses the inotropic activity of heart significantly [p<0.01] while; it does not alter the chronotropic activity significantly [p<0.01] in lower doses, but reduces this activity significantly [p<0.01] at higher doses of calcium. The result clearly supports, the Ca[++] mediated cardio toxic mechanism of heart

Assessment of role of methyl cobalamine in excitotoxic effects of glutamicaid

Neurotoxicants and environmental pollutants cause neuronal damage and may damage myelin sheath. Since Methyl cobalamine [B12] has effect on myelin sheath formation it was hypothesized that B12 administration in case of nerve damage by some neurotoxicants may be protected or corrected by B12 administration. [Braun, 1977 and Braun, 1980]. For generations physicians have recommended B-vitamins especially B12 for neuropsychiatric symptoms. In present study neuroprotective role of B12 is assessed. Present work was planned to evaluate the therapeutic or prophylactic role of B12 in nerve damage by neurotoxicant i.e. glutamic acid. Present study revealed no significant neuroprotection or defensive regimen offered by B12 for neurotoxic damage. Glutamic acid is probably affecting neurons or dentritis sparing myelin sheath. Neuroprotection expected by B12 may be applied only to myelin sheath